KMID : 0880220160540030170
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Journal of Microbiology 2016 Volume.54 No. 3 p.170 ~ p.177
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Hgc1-Cdc28?how much does a single protein kinase do in the regulation of hyphal development in Candida albicans?
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Wang Yue
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Abstract
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The fungal human pathogen Candida albicans can cause invasive infection with high mortality rates. A key virulence factor is its ability to switch between three morphologies: yeast, pseudohyphae and hyphae. In contrast to the ovalshaped unicellular yeast cells, hyphae are highly elongated, tube-like, and multicellular. A long-standing question is what coordinates all the cellular machines to construct cells with distinct shapes. Hyphal-specific genes (HSGs) are thought to hold the answer. Among the numerous HSGs found, only UME6 and HGC1 are required for hyphal development. UME6 encodes a transcription factor that regulates many HSGs including HGC1. HGC1 encodes a G1 cyclin which partners with the Cdc28 cyclin-dependent kinase. Hgc1-Cdc28 simultaneously phosphorylates and regulates multiple substrates, thus controlling multiple cellular apparatuses for morphogenesis. This review is focused on major progresses made in the past decade on Hgc1¡¯s roles and regulation in C. albicans hyphal development and other traits important for infection.
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KEYWORD
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Candida albicans, yeast-to-hyphae growth transition, cyclin-dependent kinase, polarized growth, protein phosphorylation
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